Breast Cancer And Bone Metastasis: A Critical Analysis of Traditional and Modern Treatment Strategies

Erkinova Shoxista Rustamjon kizi; Adhamjonova Uktamxon Akmalkhon kizi; Abdivokhobova Gulnozakhon Shuhratbek kizi; Yakubbekova Soxibaxon Sadik qizi

Authors

Erkinova Shoxista Rustamjon kizi 1 st year master degree students in oncology ,Andijan State Medical Institute
Adhamjonova Uktamxon Akmalkhon kizi 1 st year master degree students in oncology, Andijan State Medical Institute
Abdivokhobova Gulnozakhon Shuhratbek kizi 1 st year master degree students in oncology ,Andijan State Medical Institute
Yakubbekova Soxibaxon Sadik qizi Associate Professor of the Department of Oncology

Keywords:

breast cancer, bone metastasis, osteolytic lesions, denosumab

Abstract

Breast cancer represents one of the most prevalent malignancies worldwide, with bone metastasis occurring in approximately 65–75% of patients with advanced-stage disease. The colonisation of the skeletal system by tumour cells precipitates a debilitating cycle of osteolytic and osteoblastic destruction, significantly compromising patient survival, functional capacity, and quality of life. This review critically analyses and compares the therapeutic landscape governing breast cancer–related bone metastasis, from established modalities—including chemotherapy, endocrine therapy, and external beam radiotherapy—to contemporary advances in targeted therapy, bone-modifying agents, immunotherapy, and precision medicine.